This is a 18 mins video on the important topic of nocturia and nocturnal polyuria, which can adversely affect longivety! The usage and limitations of the hormone, ADH, antidiuretic hormone is discussed, in the context of the holistic management.
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Evening Dietary Protein Intake in the Pathogenesis of Nocturnal Polyuria
Alwis U1, Monaghan T2, Delanghe J1, Everaert K1
1. Ghent University, 2. SUNY Downstate Health Sciences University
KEYWORDS: Nocturia, Prevention, Quality of Life (QoL)
Recent research has shown that nocturnal polyuria (NP) is a heterogeneous condition that may be driven by excess nocturnal free water and/or sodium clearance. Consistently, behavioral and pharmacologic interventions targeting both nocturnal free water and sodium production have garnered considerable traction in the management of nocturia owing to NP. Relatively less attention has been afforded to urea—the most abundant urinary solute—despite the fact that urinary urea excretion is known to be highly interrelated with dietary protein intake [1]. Mechanistically, the body maintains a low concentration level of urea in both plasma and extracellular fluid, which lends to a daily urea excretion approximately two times greater the total body urea pool (and thus proportionally far greater than sodium, wherein daily excretion reflects approximately one-fifteenth of the total body sodium pool) [1]. Accordingly, it stands to reason that excretion of a large quantity of urea, as would be expected in patients following significant dietary protein intake, may reflect an additional important mediator in the pathogenesis of NP. This study aims to explore the association between NP and estimated dietary protein intake.
Read the full abstract text here: https://www.ics.org/2020/abstract/498
Is Obstructive Sleep Apnea to blame for Nocturnal Polyuria?
Auping M1, Kuipers A1, Witte L2
1. Dept. of Pulmonology, Isala Clinics, Zwolle, the Netherlands, 2. Dept. of Urology, Isala Clinics, Zwolle, the Netherlands
KEYWORDS: Nocturia, Clinical Trial, Prospective Study, Voiding Diary
Nocturia is a common urological problem with a high prevalence (up to 60%) especially in elderly patients (1). The underlying causes for nocturia are various, such as conditions causing sleeping disorders, bladder storage problems, and nocturnal polyuria. Patients with nocturnal polyuria have an increased production of urine during nighttime (i.e. one third or more of the total volume of urine produced in 24-hours) (2). Nocturnal polyuria may be present in patients with obstructive sleep apnea (OSA) and treatment with continuous positive airway pressure (CPAP) reduces nighttime frequency and nocturnal voided volume in patients with OSA (3).
In this study, we examined the amount of patients with nocturnal polyuria that suffer from OSA.
Subsequently, we offered patients with confirmed OSA treatment with CPAP, and analyzed the effect on episodes of nocturia and the nocturnal polyuria index (NPi= voided volume during night time/voided volume in 24 hours*100).
Read the full abstract text here: https://www.ics.org/2020/abstract/82
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