Diabetes 6, Glucosuria, polyuria, thirst

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Polyuria occurs as a result of an osmotic diuresis. This is a diuresis that occurs for osmotic reasons. Diuresis means an abnormally large volume of urine is produced. When the level of glucose in the blood increases there is an equivalent increase in the concentration of glucose in glomerular filtrate. The quantity of glucose the renal tubules are able to reabsorb is limited. In health, when blood glucose levels are normal, all of the glucose in the filtrate is reabsorbed; this means physiologically there is no glucose at all in urine. However, when glucose glomerular filtrate levels are abnormally high it cannot all be reabsorbed. This will result in glucose passing straight through the tubule into the urine.
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